Phentermine vs Methylphenidate (which one is more potent?)

  • By: jacob foxx
  • Date: April 3, 2023
Phentermine vs Methylphenidate

Phentermine and methylphenidate are two commonly used drugs that stimulate the CNS.

Phentermine has been approved as a treatment for obesity, and it is known for its ability to make you feel less hungry by making your brain release dopamine and norepinephrine.

On the other hand, methylphenidate is primarily used to treat ADHD, ADD, and narcolepsy. Its mechanism of action is to increase the activity of norepinephrine and dopamine in the brain.

Both drugs work to enhance the functioning of the CNS, but through different processes.

It is important to note that these drugs should only be used with a prescription and under the guidance of a healthcare professional.

Yet, can phentermine be used to treat ADHD, ADD, and narcolepsy? Is methylphenidate also beneficial for obesity?

Continue reading to learn more.

Phentermine Vs Methylphenidate Overview

What is Phentermine?

Phentermine is a stimulant for the central nervous system that is used to treat obesity.

The medicine raises the levels of neurotransmitters, which makes you feel full and reduces your appetite.

Phentermine also makes the body’s “fight or flight” response stronger, which could make people want to exercise more.

However, it should be noted that the medication has the potential for abuse and could cause serious side effects such as worsening heart conditions or heart emergencies.

Phentermine can be purchased in three forms, Lomaira (8 mg), Suprenza (15/30/37.5 mg), and Adipex-P (37.5 mg). It’s crucial to keep in mind that the medication’s price for 30 tablets ranges from $16 to $125, and insurance may not be available. 

What is Methylphenidate?

Methylphenidate is a medication that requires a prescription and is FDA-approved to treat narcolepsy, ADHD, and ADD.

The medication stimulates the brain to produce neurotransmitters, such as norepinephrine and dopamine, which can lead to an improvement in attention and a reduction in hyperactivity and impulsiveness.

Despite its efficacy, it is important to note that methylphenidate carries a “black box” warning due to its potential for abuse and dependence. If you don’t use it right, you might experience side effects like hyperactivity, restlessness, high blood pressure, less focus, anxiety, and paranoia.

Methylphenidate is available in several dosage forms and strengths, with a typical dose range of 10–60 mg per day. Some commonly known brand names of methylphenidate include Aptensio XR, Concerta, Cotempla XR-ODT, Metadate ER, and Methylin ER.

Possible Costs

The prices of methylphenidate can vary significantly depending on multiple factors, such as brand, dosage, and location.

Generic versions of 10 mg tablets for 60 pieces generally cost less, with prices starting around $58.80 at CVS Pharmacy.

However, Ritalin tablets with the same dosage and quantity come at a higher price of about $79.20. Extended-release versions tend to be more expensive, at approximately $58 for 20 pieces.

It is worth noting that generic medications may not always come in all dosages, thus necessitating a different dosage or a branded option.

It’s important to consult with a doctor or pharmacist to ensure you’re getting the best medication for your needs, while staying within your budget.

Phentermine vs Methylphenidate Side Effects

Common Phentermine Side Effects

Phentermine is a prescription medication used to help people lose weight. It can be effective, but it also has some side effects that should be taken into consideration before taking the drug.

Here are some common phentermine side effects:

  • Dry mouth
  • Difficulty sleeping
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Stomach pain
  • Increased or decreased blood pressure
  • Dizziness
  • Irritability

Phentermine Serious Side Effects

Phentermine, a weight-loss medication, comes with its own set of serious side effects. While it can help in shedding excess pounds, one needs to be cautious about the potential risks that come with its usage.

Signs of mood swings, allergic reactions, heart-related emergencies, high blood pressure, and low blood sugar indicate the severity of the side effects associated with them.

Moreover, the drug has also been linked to an increased risk of developing mood disorders such as depression and anxiety.

When taken by women who are pregnant, phentermine can cause problems like gestational diabetes, preeclampsia, and even miscarriage.

It is important to take the drug as directed and not exceed the dosage, as it has the potential for abuse.

Common Methylphenidate Side Effects

Methylphenidate is a medication used to treat Attention Deficit Hyperactivity Disorder (ADHD). It can help improve focus and attention, but it also has side effects.

Common methylphenidate side effects include:

  • Sweating
  • Increased blood pressure
  • Mood changes
  • Anxiety
  • Feeling nervous or irritable
  • Trouble sleeping
  • Decreased appetite with possible weight loss
  • Jitteriness
  • Irritability
  • Difficulty falling asleep
  • Risk of sudden death, stroke, and heart attack (for people with heart problems)

Methylphenidate Serious Side Effects

While methylphenidate can be an effective treatment for attention deficit hyperactivity disorder (ADHD), it is important to be aware of its serious side effects.

Allergic reactions, like rashes and trouble breathing, are possible, and if Concerta tablets are not taken whole, they can get stuck in the digestive tract.

See also  Garcinia Cambogia Extra review: Does it really help you lose weight

Also, the drug can make mental health problems like paranoia and hallucinations worse, which makes it a risky choice for some people.

Finally, people with heart problems should avoid taking methylphenidate due to the potential for serious cardiac events. Anyone considering this medication must weigh the potential benefits against the serious risks.

The Key Differences Between Phentermine and Methylphenidate

For those looking for a prescription drug to treat attention deficit hyperactivity disorder (ADHD), both phentermine and methylphenidate are approved by the United States Food and Drug Administration (FDA) and offered in tablet form.

However, there are key differences between the two that should be taken into account before beginning treatment.

Although insurance may cover most methylphenidate products, this is not usually the case with Phentermine; luckily, discounts and coupons are available to help make it more affordable.

In addition, while adults of any age can use Phentermine safely, it is not suitable for those below the age of 16 while methylphenidate is accepted by medical practitioners for children as young as 4, but only with a doctor’s prescription.

Furthermore, while both drugs have potential for abuse, only methylphenidate carries a black box warning from the FDA due to its potentially dangerous side effects.

Can Phentermine and Methylphenidate Be Used Together?

It is important to note that phentermine and methylphenidate are both highly potent medications and should not be taken together without professional guidance.

The potential for addiction and harmful side effects are significant when combining these substances.

Patients should consult with their physicians or healthcare providers before beginning any new medications and, especially in this case, heed their advice when it comes to mixing drugs.

So, while the urge to seek quick improvement may exist, it is essential to always prioritize safety and follow a healthcare professional’s recommendations.

Which Is the Best Option? Methylphenidate Versus Phentermine

Phentermine and methylphenidate are both CNS stimulants, but they are used and have effects that are very different.

Phentermine is primarily utilized as an appetite suppressant to manage obesity. In particular, it is often recommended for individuals whose weight puts them at risk of serious health conditions such as high blood pressure, heart disease, and diabetes.

Phentermine-named brands include Adipex-P, Lomaira, and Suprenza. Side effects of the drug include but are not limited to increased heart rate, high blood pressure, insomnia, and dry mouth.

In contrast, methylphenidate is used to manage attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), and narcolepsy.

As a CNS stimulant, it affects certain chemicals in the patient’s brain that can cause hyperactivity and make it hard to control impulses. This helps the patient pay more attention and concentrate.

The drug comes in different forms, including tablet, patch, and capsule. The commonly known brand names for methylphenidate are Concerta, Daytrana, and Ritalin.

Even though it can help treat a number of conditions, some people may abuse it by increasing the dose on their own or taking it with another drug like alcohol. This can lead to addiction, health problems, or even death.

What Is a More Effective Option to Phentermine and Methylphenidate?

When searching for weight loss options, it’s important to consider the potential risks and side effects of the methods available.

Fortunately, there is a new natural option on the market: PhenQ. This weight management system not only helps with cravings and excess fat, but it also provides natural energy for working out.

The combination of these three actions can help manage weight loss and reach goals faster.

click to find out more about PhenQ

Unlike alternatives like phentermine and methylphenidate, PhenQ has no serious side effects or potential for abuse, making it a safer long-term option.

Additionally, it also provides benefits in improving mood and reducing daily mental fatigue. Consider PhenQ to achieve your weight loss goals in a safe and effective way.


Is Phentermine the same as ADHD medication?

Phentermine is not the same as ADHD medication. Phentermine is a prescription weight loss medication that works by decreasing appetite and is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight.

It is chemically related to amphetamines and works by stimulating the central nervous system.

ADHD medications, on the other hand, are stimulants that work by increasing levels of dopamine and norepinephrine in the brain to improve focus and reduce hyperactivity.

Can Methylphenidate Be Used to Lose Weight?

Methylphenidate, or Ritalin, is a stimulant medication commonly used to treat attention-deficit/hyperactivity disorder (ADHD). It has been studied for its potential effects on weight loss and appetite suppression.

Research suggests that taking methylphenidate for a long time may make you less hungry and help you lose weight.

A study conducted in 2014 found that discontinuing the use of methylphenidate led to a significant increase in body weight. This indicates that any weight lost while taking the drug will return once it is stopped.

Is Duromine the same as Ritalin?

Duromine and Ritalin are two different medications that are used to treat different conditions. Duromine is a weight loss medication, while Ritalin is primarily used to treat Attention Deficit Hyperactivity Disorder (ADHD).

Duromine contains the active ingredient phentermine, which works by suppressing appetite and increasing metabolism. It is not recommended for use in children or adolescents due to its potential for addiction and abuse.

See also  How to Choose the Best Prime Male Testosterone Supplement

On the other hand, Ritalin is an amphetamine-based stimulant medication that helps increase focus and attention in people with ADHD. It can also be used to treat narcolepsy, but it has a higher potential for abuse than Duromine.

When Is the Best Time to Take Phentermine?

When it comes to taking phentermine for weight loss, timing is key. Phentermine is usually taken once a day in the morning, before breakfast.

For some people, taking a lower dose of phentermine up to three times a day can be more effective than taking one larger dose. It’s important to follow your doctor’s instructions when taking phentermine and not take more than prescribed.

How Does Phentermine Feel?

Phentermine is a prescription weight loss medication that works by decreasing appetite. It is a sympathomimetic amine anorectic agent and has been used clinically for more than 50 years to help people lose weight.

When taken as directed, phentermine can help reduce hunger and cravings, making you feel full and satisfied after eating smaller meals. Some people may also experience increased energy levels while taking phentermine, which can help them stay motivated to exercise and stick to their diet plan.

How Fast Does Phentermine Start Working?

Phentermine is a prescription medication used for short-term weight loss. It has been approved by the FDA for use for less than 12 weeks and works by activating your body’s natural fight-or-flight response, which helps reduce appetite.

Phentermine begins working almost immediately after you take it, with most people noticing a decrease in appetite within three to five days.

Additionally, expect great changes in your body weight within two to four weeks. After ingestion, phentermine reaches peak concentrations in 3 to 4.4 hours and has a half-life of about 25 hours.

How Long Does Phentermine Last?

Phentermine is a prescription medication used for short-term weight loss. It is usually prescribed for three to six weeks, however, recent studies have shown that it can be taken for up to 12 weeks.

Phentermine can be detected in your blood for up to 24 hours after taking it, and its effects can last anywhere from one week to several months.

When Should You Take Methylphenidate?

Methylphenidate is a medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.

It is usually taken once a day, either in the morning or 30-45 minutes before meals. For adults, the recommended dose is 18–36 milligrams (mg) per day, while teenagers aged 13–17 should take 18 mg per day.

Your doctor may increase your dosage by 8.6 to 17.3 mg each week until an effective dose is reached. It’s important to note that if taking multiple doses of methylphenidate, your last dose should be taken before 6 p.m.

How Fast Does Methylphenidate Start Working?

Methylphenidate, a central nervous system, is commonly used to treat attention deficit hyperactivity disorder (ADHD).

It typically takes about 20–30 minutes for Ritalin, the most common form of methylphenidate, to kick into your system. The peak effects from this drug are usually felt quickly and then dissipate rapidly.

When you have found the right dose for you, methylphenidate should start to work within 30 to 60 minutes of taking it.

However, it takes approximately 1.9 hours after taking a methylphenidate immediate-release tablet for it to reach its peak level in the blood. Extended-release formulations such as capsules and tablets can take up to an hour or more before they start working.


Phentermine and methylphenidate are two prescription drugs that serve different purposes in the healthcare field.

Phentermine, a weight loss drug, is prescribed to suppress appetite and increase metabolism. Methylphenidate, an ADHD medication, helps people focus and stay on task.

While both are stimulants, methylphenidate is not addictive like phentermine. It is important to note that although these medications can be effective, they come with potential side effects and risks.

I'm Jacob Foxx, a proud native of the outskirts of Chicago, Illinois. I was enamored with the expansive Star Trek universe and its promise of cutting-edge technology and space travel from a young age. This early fascination with science fiction sparked my imagination and laid the foundation for my writing career. Alongside my love for the cosmos, I developed a passion for fitness in my formative years.

This dual interest in the world of tomorrow and the pursuit of physical health has greatly informed my writing, allowing me to explore themes of human potential and the future of our species. As an author, I strive to blend these passions into compelling narratives that inspire readers to dream and to push their own boundaries.

Phentermine and Surgery Guide

Previous Post

Phentermine and Surgery Guide (Hazards, Benefits, and Duration)

Next Post

Does Phentermine Cause Hair Loss Permanently? (Can It Be Treated)

Does Phentermine Cause Hair Loss Permanently?