Phentermine vs Contrave – Which is superior? (What works best together?)

  • By: jacob foxx
  • Date: April 18, 2023
Phentermine vs Contrave

When it comes to weight loss medications, phentermine and Contrave are two popular choices.

Phentermine is a short-term appetite suppressant that delivers quick results, making it an ideal option for those looking for a fast fix.

On the other hand, Contrave is a slower weight loss medication that is perfect for long-term usage, with its effects extending for a longer duration.

Both medications work by reducing food cravings and calorie intake, making the weight loss journey more manageable.

This article will delve into the mode of action and side effects of these medications, along with clinical trials and user reviews that provide insights into their efficacy.

So, keep reading until the conclusion to learn everything there is to know about these two weight loss medications.

To begin, a basic ingredient analysis will be performed to determine how these medications work.

What is Phentermine?

Phentermine is a sympathomimetic amine that has gained popularity as an anorectic drug for treating obesity.

It is sold in the market under various names such as Phentermine HCL, Adipex-P, and Lomaira, but one thing remains the same: it can be purchased only with a prescription from a physician.

The drug works by targeting synaptic receptors in the brain and raising levels of certain neurotransmitters that help suppress appetite.

Its short-term treatment approach has provided hope for those struggling to lose weight. Its effectiveness, however, comes with possible side effects and requires close monitoring from medical professionals.

Despite this, Phentermine has proven to be a valuable tool in battling obesity for those who qualify for its use.

What is Contrave?

Orexigen Therapeutics developed Contrave, a prescription weight-loss supplement, which Currax Pharmaceuticals purchased in 2019.

Containing bupropion HCl and naltrexone HCl, this supplement has been commonly prescribed to those with a body mass index of 30 kg/m2 or higher.

Bupropion, primarily used as an antidepressant, has been known to promote weight loss when used as monotherapy, while naltrexone is an opioid antagonist used to reduce cravings for alcohol or opioids.

The two molecules work together to stimulate parts of the central nervous system, such as the hypothalamus and mesolimbic system, to suppress appetite and cravings, as well as affect the limbic reward system.

Although the exact neurochemical effects of this supplement are not fully understood yet, it has become a popular option for those struggling with weight loss.

Which is safer and more effective, phentermine or contrave?

Both diet pills claim to provide excellent results, but which should you choose? And, in the first place, are these anorectic medications safe?

To help you make an informed decision, we have gathered a list of their benefits, side effects, and user reviews.

Phentermine benefits

Phentermine is a powerful weight loss medication that offers many benefits to those struggling with extra pounds.

The medication’s hunger-curbing effects last up to 2 to 3 days, ensuring that individuals feel full and satisfied for extended periods.

This effect is due to the medication’s long half-life and its influence on serotonin and norepinephrine levels.

In a 12-week study, over 80% of participants exhibited a 5% reduction in initial weight, with more than half reporting up to 10% weight loss.

Phentermine also has mild positive effects on metabolism, increasing energy expenditure at rest by up to 35%.

Lastly, the medication’s impact on dopamine levels enhances mood and energy, making individuals feel more positive and motivated throughout the day.

Contrave benefits

Contrave is a prescription medication that has been proven to aid in weight loss. It works by targeting specific brain circuits, namely the hypothalamus and mesolimbic circuits, to help suppress the hunger response and reduce cravings.

Additionally, Contrave increases dopamine levels in the brain, which can lead to a feeling of fullness with fewer bites.

In fact, a 2010 placebo-controlled study found that users taking Contrave lost 6.1% more weight than those taking a placebo.

This medication not only helps with weight loss, but it also has mood-improving effects due to the increased presence of dopamine in the brain upon use of bupropion.

With proven results and a multi-faceted approach, Contrave can be an effective tool in achieving weight loss goals.

When it comes to achieving weight loss goals, Phentermine is often top of mind for those seeking a quick fix.

With its intense stimulative properties, it provides quicker effects than other weight loss medications.

However, it’s important to remember that sustainable weight management requires more than just a pill.

Healthy habits like a balanced diet and regular physical activity are necessary for long-term success.

For those seeking a medication that can aid in both short and long-term weight loss goals, Contrave may be a beneficial option.

It allows for lifestyle and eating habit modifications during use, making it a valuable tool for those looking to achieve lasting results.

How safe is Phentermine?

Phentermine is a well-known drug that is FDA-approved for short-term usage of up to three months.

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Despite its effectiveness in reducing weight for healthy individuals, phentermine’s status as a controlled substance limits its usage to only a few months.

On the other hand, Contrave, another weight loss medication, has received approval for long-term usage since none of its ingredients fall under controlled substances.

Although it is generally well-tolerated by healthy individuals, phentermine can pose serious health risks to pregnant women and those with underlying cardiovascular or cerebral problems.

Thus, it is crucial to consult with a healthcare professional before taking any medication to ensure one’s safety and well-being.

How safe is Contrave?

The safety of Contrave was closely monitored in a clinical trial involving 3475 individuals to assess its adverse effects.

Users reported typical side effects such as nausea (32.5%), constipation (19.2%), and headache (17.6%).

However, less than 10% of users experienced other adversities, and a negligible risk factor for cardiovascular ailments was indicated in the study.

While Contrave is generally safe, it is important to note that serious side effects such as suicidal thoughts, liver damage, vision problems, or manic behavior may occur after taking this medicine.

Due to their impact on brain cells, these side effects are comparable to those of naltrexone, bupropion, and phentermine.

It is essential for individuals to speak with their doctor before taking Contrave and to report any unusual symptoms that might develop.

Side effects of Phentermine

Phentermine is a widely used weight loss drug, but like any medication, it comes with a list of possible side effects.

Common side effects include nausea, insomnia, headache, dry mouth, palpitations, tachycardia, constipation, and thirst.

However, more severe side effects have been reported, such as pulmonary hypertension, cardiovascular diseases, and stroke.

According to scientific findings, using phentermine may also cause cardiac problems such as ventricular fibrillation and heart arrhythmias, as well as cerebral stroke and tardive dyskinesia.

Moreover, taking large doses of phentermine over an extended period of time has been linked to psychotic behavior and anti-social thoughts and interactions.

Pregnant or breastfeeding women should also avoid taking phentermine due to the risk of gestational diabetes and complications.

Side effects of Contrave

Contrave is a commonly prescribed medication for weight loss, but as with any drug, it comes with potential side effects.

Nausea, headache, dry mouth, dizziness, constipation, vomiting, sleep disturbance, and diarrhea are among the most common side effects of Contrave.

It’s important to note that serious side effects like depression, mania, hepatitis, angle-closure glaucoma, and severe allergic reactions may also occur.

Additionally, it’s worth mentioning that Contrave can reduce the efficacy of opioid-based medications and street drugs.

If you’re considering taking Contrave, make sure to tell your doctor about all other medications you use before beginning the medication.

This is especially important for pregnant women as it falls under category X and is unsuitable for breastfeeding mothers due to potential harm to infants. 

Phentermine User reviews

Phentermine has been a trusted weight-loss medication for quite some time now, and it has helped countless individuals achieve their desired body goals.

With an average monthly weight drop of 4–8 pounds, many users experience visible results within the first month of use.

The medication has proven to have a low to no risk of adverse effects, which has contributed to a high satisfaction rate among third-party forums.

Ratings on reflect this, with an impressive 8.7/10 score and 84% positive experiences.

Similarly, WebMD gives it a 4.3/5 rating from users. These numbers stand as evidence of the medication’s efficacy and the excellent results that it has produced.

phentermine user reviews

Contrave User reviews

People have used Contrave, a prescription drug, to help them lose weight. According to a popular medical website,, the drug has an average rating of 6.9 out of 10.

While 66% of users have reported positive experiences with the pill, 22% had a more negative experience.

It is worth mentioning that some users reported significant adverse effects, notably psychotic episodes and nausea.

Contrarily, other users have been able to achieve substantial weight loss. In fact, some have shed over 40 pounds in just three months, making it an attractive option for those looking to lose weight quickly.

Phentermine costs

Phentermine comes in capsule (15 mg, 30 mg, and 37.5 mg) and tablet (37.5 mg) forms. This medication has been known to aid individuals in weight loss, helping them to achieve their goals.

For those interested in buying this supplement, the prices vary depending on the quantity, with 30 tablets of 37.5 mg phentermine HCL ranging from $16.44 to $23.35.

Opting for larger quantities has its perks, with 60 tablets costing $37.20, and 120 tablets only $64.91.

These rates are certainly reasonable, making phentermine a cost-effective solution to help with one’s weight management journey.

Contrave costs

Contrave is a medication that has gained significant attention in recent years due to its ability to aid in weight loss.

Available as extended-release oral tablets, Contrave contains bupropion 90 mg and naltrexone 8 mg.

These two ingredients work together to help reduce appetite and maintain a healthy weight.

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Interested individuals can choose between two packing variations of 70 tablets or 120 tablets, depending on their treatment needs.

While the cost may be prohibitive for some, a bottle of 70 tablets costs $260.03, and a bottle of 120 tablets costs $667.84.

Phentermine Pros and Cons


  • Prescription-only medication designed to help people lose weight
  • Can suppress appetite and boost energy levels
  • Clinical trials have shown that people taking phentermine lost an average of 5 – 10 pounds more than those who weren’t taking the medication
  • Short term effects on weight loss and appetite suppression


  • Should only be taken with recommendation from a doctor
  • May cause increased blood pressure, rapid heart rate, restlessness, insomnia, or constipation
  • Possibility of physical and psychological dependence can occur with long term use

Contrave Pros and Cons


  • Prescription-only medication designed to help people lose weight
  • Combination of two drugs to reduce hunger and control cravings
  • Clinical trials have shown that people taking Contrave lost an average of 4-11 pounds more than those who were not taking the medication
  • Used in combination with a reduced calorie diet and exercise program for best results


  • Should only be taken with recommendation from a doctor
  • Increases risk of cardiovascular side effects, such as increased heart rate, chest pain, or changes in blood pressure
  • May take up to 12 weeks before seeing any significant weight loss

FAQs on Contrave vs. Phentermine

How much weight can you lose with Contrave?

Contrave is a prescription weight loss medication that combines two drugs, naltrexone HCI and bupropion HCl, to help people lose weight.

It is designed to reduce hunger and control cravings, so users can stick to their diet and exercise plans.

According to the manufacturer, clinical trials have shown that people taking Contrave lost an average of 4–11 pounds more than those who were not taking the medication.

It’s important to note that Contrave should be used in combination with a reduced calorie diet and exercise program for best results.

Additionally, it may take up to 12 weeks before you start seeing any significant weight loss

Can I take Phentermine with Contrave together?

It is not recommended to take Phentermine and Contrave together without a recommendation from your doctor.

Taking the two medications together can increase the risk of cardiovascular side effects, such as an increased heart rate, chest pain, or changes in blood pressure.

Does Contrave speed up metabolism?

Contrave is a prescription medication used to treat obesity. It is a combination of two drugs, naltrexone and bupropion, that work together to help reduce appetite, promote fullness after meals, and increase energy levels.

The drug has been known to induce weight loss in the short term, as it increases dopamine levels, which reduce appetite and boost basal metabolism.

Clinical trials have shown that Contrave can help people lose weight by modulating their appetite and influencing other stubborn fat cells.

While these drugs are not meant to replace a healthy diet and exercise regimen, they can help people curb their cravings and reach their fitness goals faster.


Phentermine and Contrave are two weight-loss medications that work by reducing hunger hormones in the brain to produce anorectic effects.

While Contrave is known for its slow weight loss process, Phentermine exhibits more potent stimulatory properties and results in faster weight loss.

Despite their similar safety profiles, caution must be exercised when using either medication.

Phentermine can potentially aggravate cardiovascular diseases, while Contrave can cause psychic problems.

Therefore, it is highly recommended that you consult a doctor before starting any weight loss medication.

I'm Jacob Foxx, a proud native of the outskirts of Chicago, Illinois. I was enamored with the expansive Star Trek universe and its promise of cutting-edge technology and space travel from a young age. This early fascination with science fiction sparked my imagination and laid the foundation for my writing career. Alongside my love for the cosmos, I developed a passion for fitness in my formative years.

This dual interest in the world of tomorrow and the pursuit of physical health has greatly informed my writing, allowing me to explore themes of human potential and the future of our species. As an author, I strive to blend these passions into compelling narratives that inspire readers to dream and to push their own boundaries.

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